Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_02820T0
SpeciesCryptococcus neoformans var. grubii H99
Gene Annotationserine/threonine protein kinase
Gene SymbolPKH201
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNC04370 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
TKL-62.20.00000082
Microbial Kinome Result
PredictionScoreE-value
ePK75.51.1e-23
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K07298 KEGG 4.9e-30 100.7
Amino Acid SequenceMSLFRELPSRNLNILSSPPDTATTASPIARTSSNSSRNDLFTTSWQPEIPPPRPLAHDNPSTATTGREEEPTADPLRSPAKISSNGVHANTMPSPMKRRDFFCYDANPITHHSNASSPAESGRNSPMLVDEFGVPKRGHVPSSVTVPAQHHNHPYSQTTNPNARQGSPRTSSFFDVVLSTDLPAPPPAPPRAIPTLHSMHASNGNSSPINLSRSTSLRRAPPPPLLPLTRTGSNSYNINGGGSDRQRSWDSYTSSIPSSPSVSASYATAEEDPLSPLHQSPQLPPSRAGQADWIPPLPPAADDIELRLLPSSTYLLGEGRYAKVYLAAYKRKRKLKIKGREELLGRIPPLGHSSFASVPVRGEDKVGAEEKKEVNEDGDGLVGGDWKLCAVKRLAPDRESQTMGLREAFFLNRLMVTSPLSEDGRSAKFSKSGRERAVSPLRDSTSQTPRQTPKHTPRRNQSRNGSVYITKLIAVKEDVEGSSHSAHARSTSDAIKSQKTMTSNGTLTRQRSSTMLPPHSPTTSPVERVAAKVSVGCSKPDITNISSFPSFPSLAQAIRQEYAAPSLSRLVLVLEHAPLGTLDRLLRTSPQLVGKKLWGRWAREGVEALEWVHGKGVVHADIKPGNLLLTTDLHIRLSDFGSSLLIHPFHPPTDGLGLGTLPFSPPELVDPSVTFSFPVDIFALGATLYQCITGREPFRGLRSIEMMHHVKKGGLWAYEEAERLSRVGEPHHEGVQAGTPYPSAWRDNYSGSTSHILAAGAGVRRAGSLRVPPTHSIVAEEPLPPGRPRLKRMTSAESVRANDDVGKSESPAGVKLWAKWVKDGAGVDPVTALLSDAGFPADASKAAAASLSRGNSQSLRRSASIKSVLPDTTSARHSPPVDTAPGTPPSHHPPLTLTVHSPSTSAPSHPSPPPSPPHSLLQRGIYESYSDGSPAMLFLDGIERVSEDVRDVLRGMLEPDQWIRYRANEVRERWDELGVGIEEEIGSEEAGQGQWEGANERE
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 1446
B YPD 30°C, concentration: 5x10^7 cells/ml 1117
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 1172
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 1103
E YPD 37°C, concentration: 5x10^7 cells/ml 1301
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 2337
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_02820 5' flanking region primer 1CCCTCGCCAGAATCAATAC
L2CNAG_02820 5' flanking region primer 2TCACTGGCCGTCGTTTTACGAGAGGATGTTGAGGTTGC
R1CNAG_02820 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGTTGGGATTAGGGCGTATC
R2CNAG_02820 3' flanking region primer 2TCTGCCTCTACAAACCACTG
SOCNAG_02820 diagnostic screening primer, pairing with B79GGAGAGACAGGGGATAAAGC
POCNAG_02820 Southern blot probe primerATACCTCCCTTCTCCCAAC
STMNAT#219 STM primerCCCTAAAACCCTACAGCAAT
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_02820T0
Mating Data
Growth phenotype for CNAG_02820T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_02820T0
Urease
Urease phenotype for CNAG_02820T0
Melanin
Melanin phenotype for CNAG_02820T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_02820T0
Oxidative Stress
Oxidative stress phenotype for CNAG_02820T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_02820T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_02820T0
ER Stress
ER stress phenotype for CNAG_02820T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_02820T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_02820T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_02820T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_02820T0