Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_00405T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationSTE/STE20/YSK protein kinase
Gene SymbolKIC1
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNA03940 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
STE309.82.1e-92
Microbial Kinome Result
PredictionScoreE-value
ePK286.21.5e-85
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K08838 KEGG 9.9e-113 375.4
Amino Acid SequenceMPASEGRYLAALPAEHKDAAPESLYQKLEIVGKGAYGAVYRGKHIATGHIVALKIINLDTEDDDVADIQKEISLLQQLMLGGSNSGGPPPNVIKYYGSLMQGPRVWIIMEYAEGGSIRTLSRAQPLKELHICLVIREVLLALAFLHKNGVIHRDIKAANILLTTQPHRILLCDFGVAALLQSSTSKRSTFVGTPYWMAPEVVTEGRMYDAKADIWSLGITLLEMAYGEPPMSGQPAARAVMLLGDKRMRAPRLEGDHWSKEMRDFVVGCLNEEPADRLSAEELSKSKWIKQQSKTPLTAMNDLIARYQAWKESGGQRQSLAAGVGASVDDDDDDLDGHSADGDWAFDTVRSRASILLDKQQSGDTAPSHLSPHTARPAPAPQSLRRLFHDESSTDPDPFQSFAHQQPPTPQTTEDSNTIKQTGRFPSPDQEDPPPLVDTDSHPPTPRKNEMDGQTIRQARLGRDGQSPTPLMITTDYSPSSNTLSATSTATYYPIETPQEPTPIARTDAGVPSPRRLRNKMSLDNLSLTPTSKTQLAAEERSKSNGGMRRPSASDARDGLRGFQFPLMTKSGPGPPATTTISTSTSTSTPTSTQPPTAGRLFPPPLNRNHSAAPAYPLADPTTTNTTTSPTGTSSPGFGGLAFGPRPPMMRQASVAVMEGRAASQSQSQAQAHALALTLAQTQAQQQQQQQQQGSTSPPTPKNAVALGVPSSVGLGRPGVSATAATTSGSAGESAGGGGQAMMIRSRSGSKAEDGHPVGLRDLLKLSPAVPDMPDLLPPSPSVANTPHKFFPSPSPLAQTTHAHAEPPLASATATATSSFPTLASTPMSAAASQRSLVSAGTTPASAPPGLAIQPAALAPVNATLGPPIRPLDLSMLESDDVFDELGRMVDDMQSWLGCVESGLEDLLAAEVDSQNA
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 2348
B YPD 30°C, concentration: 5x10^7 cells/ml 1968
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 2109
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 1575
E YPD 37°C, concentration: 5x10^7 cells/ml 2078
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 2264
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_00405 5' flanking region primer 1AAGATGAGCGTTGCGAAG
L2CNAG_00405 5' flanking region primer 2TCACTGGCCGTCGTTTTACGCGTGGTGCTAAGAACAAC
R1CNAG_00405 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGGAGGTAGACTCCCAGAATGC
R2CNAG_00405 3' flanking region primer 2TAATGTGTCAACTGCCGC
SOCNAG_00405 diagnostic screening primer, pairing with B79TTGGTTTCAAGGGGGAAC
POCNAG_00405 Southern blot probe primerAAAGTGGACCGTTTGGAG
STMNAT#201 STM primerCACCCTCTATCTCGAGAAAGCTCC
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_00405T0
Mating Data
Growth phenotype for CNAG_00405T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_00405T0
Urease
Urease phenotype for CNAG_00405T0
Melanin
Melanin phenotype for CNAG_00405T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_00405T0
Oxidative Stress
Oxidative stress phenotype for CNAG_00405T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_00405T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_00405T0
ER Stress
ER stress phenotype for CNAG_00405T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_00405T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_00405T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_00405T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_00405T0