Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_02675T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationCAMK/CAMKL/GIN4 protein kinase
Gene SymbolHSL101
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNK01630 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
CAMK343.21.8e-102
Microbial Kinome Result
PredictionScoreE-value
ePK345.52.1e-103
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K02515 KEGG 5.8e-255 771
Amino Acid SequenceMPSSSNAHDDGATNQRQATVTRKRTNGSGTRDEKQYIGQWRIGRTIGKGSSGRVKIAKHAVTGKYAAIKIVPKGLILNSRMSMSEAGARADKVLLGIEREIVIMKLIDHPNVLNLYDVWETSSELYLIMEYVPGGELFDYLVKRGRLPVSEALHYFQQIIYAVDYCHRFNICHRDLKPENLLLDKDKNIKVADFGMAAWEAGERMLETSCGSPHYASPEIVAGKAYHGSSSDIWSCGIILFALLTGRLPFDDDNIRSLLQKVKIGIFEMPDEIKDPARDLLKRMLEKDPEKRITMPEILSHPFFVSRPPRPIPGRSLVSPPTLDEVERPVNSVDEIDPDIMGNLKTLWSGVSDQEIIKALMCKDKTWEKTIYHLLIKYRNKHLENYNMEEEEYADARERRQTRKQLQSSSSPARRKGVPAQDQSARLAPLGENETVANTPVKRPQAPTPNKASRKAPPECPTPTKQVSQARGPAGPRPPNSRGTSGASNSSQAPAIVLQGATPTKELPSPHTTSSRPRPEVITTPTSPAPLNVPRVEDANLQTFLNQIADQMNRFSARSSVASQSSTSSSAVLGSDYQACLAFAAGVTPSANPSSSVTENVIEEQGQFEDAADDQTDAEVASIHSGFTASIAPQSPLTGLGLGAPSAVVRPGLHPVAGPNQQRWSYASSAGSSYQGSSVGSYAPVESPQYIHSPVEVQAPVLQAERSAPRPPPRATRPAPPPISRPLPFSPAQHAYSEPTESLLPRDTSYVIIENSELPSDASLSSWGSKSSGFKAHRGLDGFGMLKKKKLSVESVPFSSGDLGSSATSPFNSPKRSWFNNLFNFKPATCTLLSRDNVSNTREKMRKILLSIGVRTAVTEIDGHKALKCRLDEVRDNGNVTTKGVRFRVEFTRASTSQAYSTLVTLTQEKGAESLFRACFSELKHFMDSQPSTPTTLSLNRSSVEQSRSVNSSNLLPAQSYQQQRYSATSADASAGAPTSPLLSAPPIRYTASAPTTPVIDSSPRFTSPYLQLPVSPQSLQMPSY
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 2986
B YPD 30°C, concentration: 5x10^7 cells/ml 9581
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 9886
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 12153
E YPD 37°C, concentration: 5x10^7 cells/ml 11760
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 3466
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_02675 5' flanking region primer 1CAATGCCGTCATCATCAAAC
L2CNAG_02675 5' flanking region primer 2TCACTGGCCGTCGTTTTACAAGGGCGAACAGGATAATAC
R1CNAG_02675 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGCCTAATGTGAGAGCAGCAATAC
R2CNAG_02675 3' flanking region primer 2TATGTGGCAGAAACCGTG
SOCNAG_02675 diagnostic screening primer, pairing with B79GCTGTCTTGTTTGCGTTG
POCNAG_02675 Southern blot probe primerAGGAGTAGTTATCACTTCGGG
STMNAT#146 STM primerACTAGCCCCCCCTCACCACCT
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_02675T0
Mating Data
Growth phenotype for CNAG_02675T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_02675T0
Urease
Urease phenotype for CNAG_02675T0
Melanin
Melanin phenotype for CNAG_02675T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_02675T0
Oxidative Stress
Oxidative stress phenotype for CNAG_02675T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_02675T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_02675T0
ER Stress
ER stress phenotype for CNAG_02675T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_02675T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_02675T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_02675T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_02675T0