Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_06845T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationSTE/STE11/CDC15 protein kinase
Gene SymbolUnknown
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CND06250 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
STE263.61.7e-78
Microbial Kinome Result
PredictionScoreE-value
ePK301.92.8e-90
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K06683 KEGG 1.3e-145 400.1
K06683 KEGG 1.3e-145 81.4
Amino Acid SequenceMTATALSNYQLGDLLGRGASGNVYRALNFLTGETVAIKSISLLSLPPSSLPDIMSEIDLLKNLNHANIVKYKGFARDKENLWIILEYCENGSLQTILKKFGKFPESLVAVYISQVLEGLIYLHEQGVIHRDIKGANILTNKDGSVKLADFGVSSRAPTAVLDQSGKSKEGEAEVVGSPYWMAPEVIEQSGASTASDIWSVGCVVVELLEGKPPYGDLAPMQALWRIVQDESMRIPEGASPIVKDFLYHCFQKDPNLRISAKKLLRHPWMLSVKKSASSRFPIAPSLANNTLDRNIGPKANSEGITPQAQRDGDESRPESERENEKQSRQGTVRPRKKMMTVYDETVQKVQEWNEALKASPKNLSQPSASPSPSTSSASAPNSASKALPLPVKFTNLPLPKARQRGESNPPLSLFSIPLASNSKPLTSSSSQEQSMLLPLQLQNQIGQGGGLLSKNYMVSDVLERAREEGEERWDDDFADGISFSKLGRAEMHKHPRAHLHIPTALFASNASTSREEAEAEDQKTVRQNRVLALPTASSKPGRKSNLSRPVDEVEDYSDMEQAFGESEGSLEKKLRILKLKAIGRKGLMHPDDIHKYPLSPVKPRSSSRADARGNSSTSTSASASNPGAPLVSASLSSSIPIPNFPSPERSPSNPNTSSFPTLTIPSLSGTGKETNTKTESRKGDNSFLSQDAPTRSPPSSRSSSLRNQAKVGEEVEEHIKKYTENEEEDYEDIFGDANKTCPSSQEMPFKLILLPPHPLSSSSALRNGSGGGRGIGEGGISFSDPHSHINFDYPDSDEDDMIDPFAEIEDEFDTAEDLEKKLMRDKKVMMQGKVSKLVDELMVGGVGGGGLRGVCDDLFGILENSSPEMGLEAHFVAQHGLIAVLEVLESRLSRDVVVRLLKLVNLIVTSNVELLESFCLIGGIPVIIPYTSKKHSLETRLEASRFIRQLTRSALTLQMFISCRGLRILVELLDEDYALNKTLILSSLEGINSVFELQSPTPRNDFVRMFVREGVIDPLSTALLAILKDKLEDICANDDVNGKVNGEMEEGQGQERGQFMMEQASRAVGVLLFFCQVAQADARVREAFATRTIMIRLLKACDLLPRKLLVTAIKAIKHLSTSPQLIEVLQNSNAMEILVDILGKSIKGSHSNEICSHIFQTIYSMTRLSKSRQEEAASSGIIPLLKRVIQNKSPLKQFALPILCDMANAGKGSRRLLWHYDGLNLYLDLLEDPYWRVSALDAILAWMQDETARVEDVLLEKSASDSLVRCFVQASGVSFEGILDPLLKLLRLSTSLTSSLSHPPFFSRLSESLERSTKAVIKLNLLRLTKVVCECHPDKATLVERFGLAQIVERLSKQDGAVLVRELAKEILPGLLFGGDAPNPAASLRYASSGTVGEEMNGKTMKSGGRMEGKRSSRLRRTLSENVATDVLHPAPPVAPLPSIVSRCTHTKERDYEGDKKGDEGKREK
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 2610
B YPD 30°C, concentration: 5x10^7 cells/ml 1567
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 1398
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 1622
E YPD 37°C, concentration: 5x10^7 cells/ml 2027
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 1559
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_06845 5' flanking region primer 1GTTATTTGGATGCCAGAGC
L2CNAG_06845 5' flanking region primer 2TCACTGGCCGTCGTTTTACATGCGGTTACCTCATTCG
R1CNAG_06845 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGAGGGAGAAGTAGTTTCGGG
R2CNAG_06845 3' flanking region primer 2GGATGATAAAGAGGCAGAGAC
SOCNAG_06845 diagnostic screening primer, pairing with B79GCAAAAACCGAGACTGTG
POCNAG_06845 Southern blot probe primerTTGAGGGGTTATGCCTTC
STMNAT#201 STM primerCACCCTCTATCTCGAGAAAGCTCC
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG