Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_06310T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationCAMK/CAMKL protein kinase
Gene SymbolIRK7
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNN00400 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
CAMK27.60.000000000000049
Microbial Kinome Result
PredictionScoreE-value
ePK157.06.4e-47
Functional Annotation N/A
Amino Acid SequenceMTQPVLRKSKSNLRQRLGLAAAASKPTHLSPIASPSTTNLASSTSTTISVISRTDSRSAFTYDSATPSPPTKRMDFDTVSYNSAMSASPGEYTEEDDMSASTLVSSEDAHQQQQLTQQNTHTQPYQPPAQFHPPGEETVHPNIVTVTSGADDIFSLTDQQLSDRFTFISEIGFGNWGSVWLCKPKHVRSSQLSEPGAVVKLGKQAAASGGSGAGGKVAIKLVHRSKTATTAARVRALWGEMKIIRALRHEPHPSIIQFESFVITPSYALVIMPHLSHLIPVCLPPSRATPYFRQLASAVGYLHERGITHNDIKPANVLLSRTDIPVLVDFGFAQKWDVGARGSFLSSISWGTPEYLDPQRAKGMPHDERASDVWSLGITMFEILIGRTPFEADEQEQFSTPEELVIYYERTRKGQWVGQWSIPSDIETLLRQMINPDPANRVSAMEAYHHPALQPEAPGVIITPHFVRAAASFDVEEPLPAPLPQTHVVAEDHTQAKGDREKEKEKKEKEKRKSKRKAKRDHATSHDPHSHSHFHVRAMTPALGESIKQHTSVSKPKRDDADLASGVGSGIGDGKENEHMEVGEGEKKEKEKKRSKLVIRKLRVEEEGDDKDVGEDPTPTKVTKPAQPLTIKEYSYIADKKVVPRTSNSQLTNLSRPNSANPATTIASSTTNASKTTKEISRATSTQTFKETKDKRISTFSSDDAPEDKQAAVLRTMRLLEGTHKHYATSQREKAQEAFGAITRPAPEPPATVKKEMARPTSLDSAQALANGEKGKKEKSDERRSLGLERIGFGLASGKEKIDEEKIQKPMAAPMSPSRAKRVSTSRMPTPSPQKTRRQGIRPHTEIDATTGKIFPASDDESPLAELREKIIVSDQENLVRFRQVPGNEGELGRGDEVENLKESTAPLLIQNAHAHAYPDQRASRAAALAETHQARCSAEIKSVPEVSKRGSQGSTAPHSASVSGLTRTKSIEALAMDNRLDKMASWIKNVETIIEDARKAVAEGREPGLPVLSLPAELTTADPSTNSNVIQTTVAHRFGVTPDKATAIPSHLRTSSIQVEPATPPKWMTYAEAEEKIQAANAWLEEQQQGKRRKERPTVGHVLKLFGGEKEKAGSRSSTPDPNHHLVPLKSQGQTLRGVPSTPALRGSISGAAAAAARQSKMPHRKSESNLRNFNTMPVISSPSFVAGPQYDPDTDEDHDTATQHNSNRTRSNTNTIAFASPRRVRYETLLSGEPGVTRQGEGWTSNNIKITSYQRKEVKPSSSMASLRERARALLGDSRERERHIIDLSRKPASGVDGHAQGSGSGVGARESLKVERRSSRLTLRGEKGVKKDTAINVASGNTTEHSARPNTPAAESVLGMRSGTTGGDKKMKGWVKSLKGAMGMGKA
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 1676
B YPD 30°C, concentration: 5x10^7 cells/ml 518
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 550
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 464
E YPD 37°C, concentration: 5x10^7 cells/ml 794
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 1745
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_06310 5' flanking region primer 1GGTGCTAAAGGATGGTATGG
L2CNAG_06310 5' flanking region primer 2TCACTGGCCGTCGTTTTACGTTGCTGTTGTTTCTGTAGGTC
R1CNAG_06310 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGTTGGTTATCCGCTTACGAC
R2CNAG_06310 3' flanking region primer 2GTATGGCTATCAACCTGCTG
SOCNAG_06310 diagnostic screening primer, pairing with B79CCGACCAAGATGAAAAGC
POCNAG_06310 Southern blot probe primerGATAGCAACTTTACCCCCC
STMNAT#208 STM primerTGGTCGCGGGAGATCGTGGTTT
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_06310T0
Mating Data
Growth phenotype for CNAG_06310T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_06310T0
Urease
Urease phenotype for CNAG_06310T0
Melanin
Melanin phenotype for CNAG_06310T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_06310T0
Oxidative Stress
Oxidative stress phenotype for CNAG_06310T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_06310T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_06310T0
ER Stress
ER stress phenotype for CNAG_06310T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_06310T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_06310T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_06310T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_06310T0