Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_05558T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationCAMK/CAMKL/Kin4 protein kinase
Gene SymbolKIN4
Kinase SuperfamilyKA1-like
Kinase FamilyKinase associated domain 1, KA1
KEGG Linkout KEGG::CNH02070 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
CAMK279.43e-83
Microbial Kinome Result
PredictionScoreE-value
ePK288.33.3e-86
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K07198 KEGG 2.4e-114 369.4
Amino Acid SequenceMHQQRAPAAHHHSYSFAPYPHASISAGSTVPSMAQPQVYYQQPPADFYPQVPDHNPHIGASHGTQAGPSQSSENNALATPDVRQSKSARPRPPPSSITMPMIPTSLPDPSMHSYVPVQAPAPQQPTRTANRRSHNPAATLNSPSAPRPEELTDEYVLHPSVYAFKQEYPRRAMVGLGPYIVLQTLGEGEFGKVKLGVHADYGVEVAIKLIRRGDLQEEAHASKVEREINVLKTLKHPNIVRMFDVLDTHKYIGIVLEFAGGGELFEYILANEYLKDKEGQRIFAQLISGVDYLHKKGVIHRDLKLENLLLDKNRNLIITDFGFANQFDLSKGDLMSTSCGSPCYAAPELVVLDTPYHGSAVDIWSCGVILYAMLAGYLPYDDDPDNPDAGNVVELYRYIMNTELHYPDHVSPLGKNLLQHMLILHPEHRIKIPAIVKHPWLKPYHDMFNKSVEECEAAFQDSMYRKSKQARKELQERRRVQIQAREALQARERAHMQRSQSSAPGTIITAAALDQIRRRPHSAMPGSTPLPEIIAKHSESVDDVPLTMRSATPPAALSQPAEIRSPAIESPRPRSESMAPGLSFATSINTPTAMTVETPSSVPMHSPDGALSPAVMTAMQPSVETVSPVRDHKNRRTIQMEYAGEAAYDRTKEAFDANHGCANGSMETTSTADTGMVASSLLDVKREESTDIEMESGSSDNEQPKPASDSITQQSGEKSMDTSPIVPITIPLAPPAEFGIATVANDPSQVIEPLEKLPPASAEHEPDSIDEMTSPSTPRVSTSVEEEPVNVTPRAKMRAAPVATTPKASLVNERKRHGFMPPPMDASFVSDSQPESSLTATGLPRPPKKDRYRKGMSLDKFGLAKLLGHASQAHTTVHGEGKMSPPSASSSALALQHQLQQHGDQSQAMSQSDSVKKSRRRTLQFGFHSRRESKASSAVAAPGTPLMDKDINGENMLSSITGGTASLRDKRRKTVQIGPSTQSEQKDTTVNVSGLSSSGHLVKNPATEPPQKISVGPVVGTDASALSQNSPSTVALDAFTAQQGHYPSYRGSSSRTSKVMDWFRRKTFVKETVPERKSPALKSDSQSSFVRVGEVASPASKAQESAQASTVSQENTDETEEKIGSTADRGNTTKATPTKSSVLPRPVDADATPPSVMVTPPRPTAAATPTIGSSTQQSPPTTIGTRSASTFTFDESKIRVHTGLVDQSALSTKSPQDVFVEVIQVLRGMGVEMKRESDFKLRCTRAKKKAAGSSIGLGSVISTGSGMNPFSVMNNASTSKTDSRGLPTPMSPSVTNRSSAGIKGLLRRGSSRSSAHPARLTRTDNEVPNPPSQSTPNLELPESSMASKPEPLYGKELMDAGDEVKFTVELCKMKNLPGLFILKIKRTKGNLWSFKFIYQTVIERTTTLTH
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 2946
B YPD 30°C, concentration: 5x10^7 cells/ml 2134
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 2183
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 2112
E YPD 37°C, concentration: 5x10^7 cells/ml 2909
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 3721
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_05558 5' flanking region primer 1ATTCAATGGAGCGGGAGTG
L2CNAG_05558 5' flanking region primer 2TCACTGGCCGTCGTTTTACCGAATAAGAATGATGGTGAGCG
R1CNAG_05558 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGTCTGTTGAGGAATGCGAGGC
R2CNAG_05558 3' flanking region primer 2ATCCATTGACTTCTCTCCG
SOCNAG_05558 diagnostic screening primer, pairing with B79ATTCTGGTATGAAGCCTCGCAGCC
POCNAG_05558 Southern blot probe primerTTCCAACTTCAGGTCACG
STMNAT#225 STM primerCCATAGAACTAGCTAAAGCA
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_05558T0
Mating Data
Growth phenotype for CNAG_05558T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_05558T0
Urease
Urease phenotype for CNAG_05558T0
Melanin
Melanin phenotype for CNAG_05558T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_05558T0
Oxidative Stress
Oxidative stress phenotype for CNAG_05558T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_05558T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_05558T0
ER Stress
ER stress phenotype for CNAG_05558T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_05558T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_05558T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_05558T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_05558T0