Kinase Browser

Detailed locus information, expression profile, gene disruption strategy, and phenotype assay data.

Detailed Locus Information for CNAG_03670T0
SpeciesCryptococcus neoformans var. grubii H99
Gene AnnotationIRE protein kinase
Gene SymbolIRE1
Kinase SuperfamilyProtein kinase-like (PK-like)
Kinase FamilyProtein kinases, catalytic subunit
KEGG Linkout KEGG::CNB01690 
Genome Browser JBrowse link goes here. Sequence information also available from JBrowse.
Kinase Prediction
Kinomer Result
PredictionScoreE-value
CAMK7.80.0000000000000052
Microbial Kinome Result
PredictionScoreE-value
ePK172.62.2e-51
Functional Annotation
KEGG Annotation
KO AccessionE-valueScore
K08852 KEGG 1.6e-190 633.7
Pfam Annotation
Pfam AccessionE-valueScore
PF06479 Pfam 3.5e-44 148.1
Amino Acid SequenceMLYFLFLLPLLIAYAAPEPAALIPFPHHTLRALAPSSTATLPVQIDHDLHPLVLVSTIDGALHALERSTGKEKWVLEGDPLVGGKMKGGVEEYIVEPLSGSLYVHEDKDGEMRMRKLPLSVDQLIELSPFTFPESPTQIFTGSKHTSLMSVDLRTGEQVDCFSPTANLSQYDGSSVCDDLDDLERRGSSQRDTLFIGRTDYRLTIHSPSSSQGLSTYTSAAYPAEKKSAPAVQEISYSTYTPNAYNRPLAESWVKAGVAHQSWGPDNEEPRIRIELGFNGKALGVKPGGGLIWNRELEHIGVGVYEILIPRENPLGAPILVPQPPAHLPALFPGQNDPRAFNIHDAPPSTYIATLPECLTLPSSNTTSGNATAGNKDTKPLHFALSSSSYPLINFARPPPPGHLSDGLFYNADDGDSSDLDHSRGRGLLSGLIDPPREHETIDPPFIERQAGPAKNGWWRWVVALGMLLILLGGVMVRFGRGKGSVPGSVESKVDEKMPLLAVPVHEVRLEEKEEEEEEDVLPVVKSAPVVRIQEPSSTPEDSPPRSEGTPETHQTATPPPKKKSTRRRVRGKKKKPDATTTATAAGLTAEERDGENEDEDHEKDKEDFSPRATPKGGNKPLPELPRELSSTDLLDYDQDKERLAISDTIIGFGSHGTVVLKGTWGGRPVAVKRLLSDFTRLASQEVKLLQASDDHPNVIRYYCQEKRDNFLYIALDLCQASLADLIESPEKHRELADQLDRKRALMEVTKGLKHLHGMKIIHRDIKPQNVLVSQTPSGLRILVSDFGLARRLGQDQSSFAPTANNLAGSLGWRAPECIRGVVRLNEGFDASSSVGSSGGIANAEDGVARSRLTKAVDLFALGCLYFWVLLSGEHPFGETYNRESNIVKGEAVNMGMLSLLGEEREEVEDLVKMLLSTEPDARPSTSECLTHPIFWPAAKRLGFLCDASDRFEIMQTEPAEPTLVLLEQGAQSVVGKDWYSRLDKTFTGSLGKYRKYKGGSVRDMLRAMRNKKHHYQDLEPAVQKHLGALPAGFLLYFSSRYPKLLMHVYRTVKESELREESMFEGCFQEAV
Expression Data
Notation Condition Normalized Raw Expression
A YPD 30°C, concentration: 2x 10^8 cells/ml 2715
B YPD 30°C, concentration: 5x10^7 cells/ml 2546
C YPD 30°C, fluconazole treatment, concentration: 5x10^7 cells/ml 2669
D YPD 30°C, SDS 0.01% treatment, concentration: 5x10^7 cells/ml 2577
E YPD 37°C, concentration: 5x10^7 cells/ml 2389
F YP+galactose 30°C, concentration: 2x10^8 cells/ml 3818
Gene Disruption Strategy
Mutant construction design
Primer NameDescriptionPrimer Sequence
L1CNAG_03670 5' flanking region primer 1GCCCCATCATCATAATCAC
L2CNAG_03670 5' flanking region primer 2GCTCACTGGCCGTCGTTTTACACTATGTGTCCATCTGAGGC
R1CNAG_03670 3' flanking region primer 1CATGGTCATAGCTGTTTCCTGAGTGAGTTGAGGGAGGAAAG
R2CNAG_03670 3' flanking region primer 2GAAGAAGAGCGTCAAGAAGG
SOCNAG_03670 diagnostic screening primer, pairing with B79AGGAATACGAGGTTTATCGG
POCNAG_03670 Southern blot probe primerAGCATTAGGGGTGTAGGTG
STMNAT#224 STM primerAACCTTTAAATGGGTAGAG
STM commonSTM common primerGCATGCCCTGCCCCTAAGAATTCG
Phenotype Assays
Growth
Growth phenotype for CNAG_03670T0
Mating Data
Growth phenotype for CNAG_03670T0
Virulence Factor Production
Capsule
Capsule phenotype for CNAG_03670T0
Urease
Urease phenotype for CNAG_03670T0
Melanin
Melanin phenotype for CNAG_03670T0
Stress Response and Adaptation
Osmotic Stress
Osmotic stress phenotype for CNAG_03670T0
Oxidative Stress
Oxidative stress phenotype for CNAG_03670T0
Heavy Metal Stress
Heavy metal stress phenotype for CNAG_03670T0
Cell Wall Stress
Cell wall stress phenotype for CNAG_03670T0
ER Stress
ER stress phenotype for CNAG_03670T0
Genotoxic Stress
Genotoxic stress phenotype for CNAG_03670T0
Antifungal Drug Susceptibility
Antifungal drug susceptibility for CNAG_03670T0
Virulence Data by the Insect Host Model (Galleria mellonella)
Galleria mellonella virulence data for CNAG_03670T0
Lung Infectivity Data by the Signature-tag Mutagenesis-based Murine Host Model
STM murine host model data for CNAG_03670T0